Invention Grant
US08168617B2 Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
失效
复方泛酸酯新戊酰磺酰酯环化释放前药的acamprosate，其组合物和使用方法
- Patent Title: Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
- Patent Title (中): 复方泛酸酯新戊酰磺酰酯环化释放前药的acamprosate，其组合物和使用方法
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Application No.: US12205031Application Date: 2008-09-05
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Publication No.: US08168617B2Publication Date: 2012-05-01
- Inventor: Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
- Applicant: Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
- Applicant Address: US CA Santa Clara
- Assignee: XenoPort, Inc.
- Current Assignee: XenoPort, Inc.
- Current Assignee Address: US CA Santa Clara
- Agency: Dorsey & Whitney LLP
- Main IPC: A61K31/66
- IPC: A61K31/66 ; A61K31/255 ; C07F9/02 ; C07C309/04
Abstract:
Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
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