Invention Grant
US08168643B2 Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
有权
S-腺苷-L-高半胱氨酸水解酶的可逆抑制剂及其用途
- Patent Title: Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
- Patent Title (中): S-腺苷-L-高半胱氨酸水解酶的可逆抑制剂及其用途
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Application No.: US11649996Application Date: 2007-01-05
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Publication No.: US08168643B2Publication Date: 2012-05-01
- Inventor: Chong-Sheng Yuan
- Applicant: Chong-Sheng Yuan
- Applicant Address: US CA San Diego
- Assignee: General Atomics
- Current Assignee: General Atomics
- Current Assignee Address: US CA San Diego
- Agency: Morrison & Foerster LLP
- Main IPC: A61P37/06
- IPC: A61P37/06 ; C07D473/34 ; C07D487/04 ; A61K31/52 ; A61P31/14 ; A61P35/00
Abstract:
The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used in combination with an anti-hemorrhagic viral infection agent, an immunosuppressant, a homocysteine lowering agent, or an anti-neoplasm agent. The compositions and methods of the present invention can be used for the prevention and treatment of hemorrhagic virus infection, autoimmune diseases, autograft rejection, neoplasm, hyperhomocysteineuria, cardiovascular disease, stroke, Alzheimer's disease, or diabetes.
Public/Granted literature
- US20070129386A1 Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof Public/Granted day:2007-06-07
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