Invention Grant
US08168653B2 Mediators of hedgehog signaling pathways, compositions and uses related thereto
有权
刺猬信号通路的调解者，与之相关的组合物和用途
- Patent Title: Mediators of hedgehog signaling pathways, compositions and uses related thereto
- Patent Title (中): 刺猬信号通路的调解者，与之相关的组合物和用途
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Application No.: US12848466Application Date: 2010-08-02
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Publication No.: US08168653B2Publication Date: 2012-05-01
- Inventor: Oivin M. Guicherit , Edward Andrew Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. Mackinnon
- Applicant: Oivin M. Guicherit , Edward Andrew Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. Mackinnon
- Applicant Address: US MA Lexington US CA South San Francisco
- Assignee: Curis, Inc.,Genentech, Inc.
- Current Assignee: Curis, Inc.,Genentech, Inc.
- Current Assignee Address: US MA Lexington US CA South San Francisco
- Agency: Millen, White, Zelano & Branigan, P.C.
- Main IPC: A61K31/4427
- IPC: A61K31/4427 ; C07D471/04 ; C07D413/02 ; C07D401/02
Abstract:
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
Public/Granted literature
- US20100317660A1 Mediators of hedgehog signaling pathways, compositions and uses related thereto Public/Granted day:2010-12-16
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