Invention Grant
US08168656B2 Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
失效
吲哚乙酸和茚乙酸衍生物作为具有降低的胃肠道毒性的治疗剂
- Patent Title: Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
- Patent Title (中): 吲哚乙酸和茚乙酸衍生物作为具有降低的胃肠道毒性的治疗剂
-
Application No.: US12319262Application Date: 2009-01-05
-
Publication No.: US08168656B2Publication Date: 2012-05-01
- Inventor: Lawrence J. Marnett , Jeffery J. Prusakiewicz , Andrew S. Felts , Chuan Ji
- Applicant: Lawrence J. Marnett , Jeffery J. Prusakiewicz , Andrew S. Felts , Chuan Ji
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: A61K31/47
- IPC: A61K31/47 ; C07D453/02
Abstract:
The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and modulate the activities of other polypeptides such as the class of peroxisome proliferators-activated receptors (PPARs) and γ-secretase. Also provided are methods of using the derivatives to treat pathological disorders.
Public/Granted literature
Information query
