Invention Grant
- Patent Title: Compounds having CRTH2 antagonist activity
- Patent Title (中): 具有CRTH2拮抗活性的化合物
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Application No.: US12357821Application Date: 2009-01-22
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Publication No.: US08168673B2Publication Date: 2012-05-01
- Inventor: Richard Edward Armer , Carole Eliane Andree Maillol , Colin Richard Dorgan , Graham Michael Wynne , Julia Vile
- Applicant: Richard Edward Armer , Carole Eliane Andree Maillol , Colin Richard Dorgan , Graham Michael Wynne , Julia Vile
- Applicant Address: GB Oxon
- Assignee: Oxagen Limited
- Current Assignee: Oxagen Limited
- Current Assignee Address: GB Oxon
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: GB0801131.4 20080122; GB0801672.7 20080130
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/10

Abstract:
Compounds of general formula (I) wherein W is chloro or fluoro; Z is a group SO2R1; wherein R1 is —C3-C8 cycloalkyl or heterocyclyl optionally substituted with one or more substituents chosen from halo, —CN, —C1-C6 alkyl, —SOR3, —SO2R3, —SO2N(R2)2, —N(R2)2, —NR2C(O)R3, —CO2R2, —CONR2R3, —NO2, —OR2, —SR2, —O(CH2)pOR2, and —O(CH2)pO(CH2)qOR2 wherein each R2 is independently hydrogen, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
Public/Granted literature
- US20090192195A1 Compounds Having CRTH2 Antagonist Activity Public/Granted day:2009-07-30
Information query
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