Invention Grant
US08168805B2 Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol
有权
光学活性甲基羟基氨基丙醇化合物及其作为制备（S） - （ - ） - 3-甲基氨基-1-（2-噻吩基）丙-1-醇的中间体的用途
- Patent Title: Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol
- Patent Title (中): 光学活性甲基羟基氨基丙醇化合物及其作为制备（S） - （ - ） - 3-甲基氨基-1-（2-噻吩基）丙-1-醇的中间体的用途
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Application No.: US12120748Application Date: 2008-05-15
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Publication No.: US08168805B2Publication Date: 2012-05-01
- Inventor: Bo-Fong Chen , Jinun-Ban Yeh , Weichyun Wong
- Applicant: Bo-Fong Chen , Jinun-Ban Yeh , Weichyun Wong
- Applicant Address: TW Taoyuan
- Assignee: SCI Pharmtech, Inc
- Current Assignee: SCI Pharmtech, Inc
- Current Assignee Address: TW Taoyuan
- Agency: Sughrue Mion, PLLC
- Main IPC: C07D333/20
- IPC: C07D333/20
Abstract:
The present invention provides an (S)-methylhydroxylaminopropanol derivative and the (S)-methylhydroxylaminopropanol derivative of the present invention is used as an intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol derivative is used as an intermediate.
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