Invention Grant
- Patent Title: Process for the preparation of pregabalin
- Patent Title (中): 制备普瑞巴林的方法
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Application No.: US12666133Application Date: 2008-03-24
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Publication No.: US08168828B2Publication Date: 2012-05-01
- Inventor: Manne Satyanarayana Reddy , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Revu Satyanarayana
- Applicant: Manne Satyanarayana Reddy , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Revu Satyanarayana
- Applicant Address: IN Andhra Pradesh Hyderabad
- Assignee: MSN Laboratories, Limited
- Current Assignee: MSN Laboratories, Limited
- Current Assignee Address: IN Andhra Pradesh Hyderabad
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Priority: IN1344/CHE/2007 20070625; IN114/CHE/2008 20080114
- International Application: PCT/IN2008/000174 WO 20080324
- International Announcement: WO2009/001372 WO 20081231
- Main IPC: C07C237/06
- IPC: C07C237/06 ; C07C227/30 ; C07C229/12
Abstract:
The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.
Public/Granted literature
- US20100179345A1 NOVEL PROCESS FOR THE PREPARATION OF PREGABALIN Public/Granted day:2010-07-15
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