A driver circuit includes a mode control unit and a plurality of source drivers to drive a display panel including N pixel cells on each scan line. Each source driver has M driving channels, and a first subset of the driving channels and a second subset of the driving channels are respectively in a first mode and a second mode according to a preset mode sequence, wherein M≧N. The 1st through Nth driving channels of a first source driver and the Mth through (M−N+1)th driving channels of a second source driver respectively drive the 1st through Nth pixel cells during a first scan period and a second scan period. The modes of the Mth through 1st driving channels of the second source driver are respectively altered to match the modes of the 1st through Mth driving channels of the first source driver by the mode control unit.