A driver circuit includes a mode control unit and a plurality of source drivers to drive a display panel including pixel cells on each scan line. Each source driver has M driving channels, and two subsets of the driving channels are respectively in a first mode and a second mode according to a preset mode sequence. The 1st through Nth driving channels of each of first source drivers and the Mth through (M−N+1)th driving channels of each of second source drivers respectively drive the pixel cells during a first scan period and a second scan period, wherein M≧N. The modes of the Mth through 1st driving channels of the second source drivers are respectively altered to match the modes of the 1st through Mth driving channels of the first source drivers by the mode control unit.