A cross-layer optimization framework for designing of multi-radio/multi-channel wireless mesh networks with network coding to support multiple unicast applications is used. A column-generation-based primal-dual method is used to solve the optimization problem. For network-layer formation, a code construction scheme based on linear programming is used. Delay constraints are imposed on the network code construction so the possible impact of the extra decoding delay to the upper-layer Transmission Control Protocol/Internet Protocol (TCP/IP) performance may be reduced without changing the upper-layer protocols.