A method and apparatus for controlling interference between cells for non-real time data transfer in a mobile communication network is provided. The method of controlling interference between cells in a mobile communication system including a plurality of cells includes: dividing each cell into at least one segment based on density of terminals within each cell and distance from the center of each cell; allocating rise over thermal (RoT) with respect to each segment based on the distance from the center of each cell, an attenuation ratio according to the distance, and a shadowing factor; and providing data services to terminals within each segment according to the allocated RoT. Accordingly, it is possible to improve system throughput.