In a method and apparatus for controlling operation of a wireless device, a host assembly of the wireless device enters into a handshaking procedure with firmware of the wireless device to initiate entry into or exit from a host sleep mode. Before such entry or exit, the handshaking procedure may require the host assembly to send an initiation handshake signal to the firmware, and require the firmware to send a confirmation handshake signal back to the host assembly. Entry or exit may be delayed until after the confirmation signal is received. The confirmation signal may vary depending on the handshaking configuration and activation data, and the confirmation signal may vary depending on whether the wireless device is in a power save mode or not.