An adaptive critical low level management system is described. In some embodiments, the system includes a configuration module configured to receive a service level setting and a storage module configured to receive usage information for at least one inventory of at least one type of medical item. The system also includes a processor configured to adaptively determine a critical low level based on the usage information and the service level setting, and an analysis module configured to determine when the critical low level has been reached by the at least one inventory of the at least one type of medical item, and to produce an output indication that the critical low level has been reached.