In one embodiment, a processor comprises a circuit coupled to receive an indication of a memory operation to be executed in the processor. The circuit is configured to predict whether or not the memory operation is misaligned. A number of accesses performed by the processor to execute the memory operation is dependent on whether or not the circuit predicts the memory operation as misaligned. In another embodiment, a misalignment predictor is coupled to receive an indication of a memory operation, and comprises a memory and a control circuit coupled to the memory. The memory is configured to store a plurality of indications of memory operations previously detected as misaligned during execution in a processor. The control circuit is configured to predict whether or not a memory operation is misaligned responsive to a comparison of the received indication and the plurality of indications stored in the memory.