Systems and methods for managing acronym expansions are described. In one example, the method comprises creating from the plurality of identified expansions a case-insensitive group of identified expansions, wherein each identified expansion of the case-insensitive group match in a case-insensitive manner the other identified expansions of the case-insensitive group. The method also comprises assigning a weight to the text source location for each identified expansion in the case-insensitive group. The method further comprises creating from the case-insensitive group at least one case-sensitive group of identified expansions, wherein each identified expansion of the case-sensitive group of identified expansions match in a case-sensitive manner the other identified expansions of the group of case-sensitive identified expansions. The method also comprises for each case-sensitive group of identified expansions, determining from the weights of the text source locations for the identified expansions a total weight. The method further comprises comparing the total weights for the at least one group of case-sensitive identified expansions. The method also comprises selecting a first group of case-sensitive identified expansions from the at least one group of case-sensitive identified expansions upon comparing the total weights. The method further comprises associating an identified expansion corresponding to the first case-sensitive group of identified expansions to the potential acronym.