A stoma wipe and adhesive remover is for use by an ostomy patient in cleaning a stoma and the area of skin surrounding the stoma, also known as the peristomal skin. The stoma wipe includes a convenient, pre-moistened and disposable towelette. The towelette includes an absorbent fibrous web of material into which is absorbed a liquid cleaning solution having a soap component, an emulsifying component, a water component and an antifungal component. The wipes can be packaged in a convenient, portable, re-sealable package. The stoma wipe is suitable for cleaning a stoma and its surrounding skin area without causing irritation to the stoma and the surrounding skin area, while at the same time removing adhesive residue from an ostomy appliance. The cleaning of the skin and removing old adhesive residue improves adherence of the stoma pouch to the skin area surrounding the stoma.