Invention Grant
US08173148B2 Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid
有权
包含水不溶性聚合物和有机液体的稳定的聚合物递送系统
- Patent Title: Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid
- Patent Title (中): 包含水不溶性聚合物和有机液体的稳定的聚合物递送系统
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Application No.: US11667433Application Date: 2005-11-10
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Publication No.: US08173148B2Publication Date: 2012-05-08
- Inventor: Eric Dadey , Mingxing Zhou
- Applicant: Eric Dadey , Mingxing Zhou
- Applicant Address: US CO Fort Collins
- Assignee: Tolmar Therapeutics, Inc.
- Current Assignee: Tolmar Therapeutics, Inc.
- Current Assignee Address: US CO Fort Collins
- Agency: Schwegman, Lundberg & Woessner P.A.
- International Application: PCT/US2005/040855 WO 20051110
- International Announcement: WO2006/053175 WO 20060518
- Main IPC: A61F13/00
- IPC: A61F13/00 ; A61K9/70 ; A61K38/00
Abstract:
The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.
Public/Granted literature
- US20080299168A1 Stabilized Polymeric Delivery System Public/Granted day:2008-12-04
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