Invention Grant
- Patent Title: Pharmaceutical composition comprising phenylamidine derivative and method of using the pharmaceutical composition in combination with antifungal agent
- Patent Title (中): 包含苯基脒衍生物的药物组合物和将该药物组合物与抗真菌剂组合使用的方法
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Application No.: US12443750Application Date: 2007-10-03
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Publication No.: US08173157B2Publication Date: 2012-05-08
- Inventor: Hiroshi Nishikawa
- Applicant: Hiroshi Nishikawa
- Applicant Address: JP Tokyo
- Assignee: Toyama Chemical Co., Ltd.
- Current Assignee: Toyama Chemical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2006-274709 20061006
- International Application: PCT/JP2007/069341 WO 20071003
- International Announcement: WO2008/044562 WO 20080417
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61M36/14 ; A01N25/00 ; A01N43/00 ; A61K31/74 ; A61K9/48 ; A61K9/64 ; A61K9/20 ; A61K31/435 ; A61K31/445 ; C07D401/00 ; C07D211/00 ; C07C229/00
Abstract:
A pharmaceutical composition comprising a phenylamidine derivative or a salt thereof, represented by a general formula, wherein R1 and R2 may be same or different, and represent an optionally substituted C3-4alkyl group; and one or more agents selected from azole antifungal agents, polyene antifungal agents, candin antifungal agents and fluoropyrimidine antifungal agents, and a method for combination use of the phenylamidine derivative or a salt thereof and the agents are useful for treating fungal infections caused by a fungal pathogen.
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