Invention Grant
US08173163B2 Polymeric drug delivery compositions and methods for treating ophthalmic diseases
有权
聚合物药物递送组合物和治疗眼科疾病的方法
- Patent Title: Polymeric drug delivery compositions and methods for treating ophthalmic diseases
- Patent Title (中): 聚合物药物递送组合物和治疗眼科疾病的方法
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Application No.: US12390255Application Date: 2009-02-20
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Publication No.: US08173163B2Publication Date: 2012-05-08
- Inventor: Joachim B. Kohn , Isaac John Khan , Carmine P. Lovine
- Applicant: Joachim B. Kohn , Isaac John Khan , Carmine P. Lovine
- Applicant Address: US NJ New Brunswick
- Assignee: Rutgers, The State University of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Fox Rothschild LLP
- Main IPC: A61K9/14
- IPC: A61K9/14

Abstract:
Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol com-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.
Public/Granted literature
- US20090238858A1 Compositions and Methods for Treating Ophthalmic Diseases Public/Granted day:2009-09-24
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