Invention Grant
- Patent Title: Drug carrier and drug carrier kit for inhibiting fibrosis
- Patent Title (中): 用于抑制纤维化的药物载体和药物载体试剂盒
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Application No.: US11793736Application Date: 2005-12-22
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Publication No.: US08173170B2Publication Date: 2012-05-08
- Inventor: Yoshiro Niitsu , Junji Kato , Yasushi Sato
- Applicant: Yoshiro Niitsu , Junji Kato , Yasushi Sato
- Applicant Address: JP Ibaraki, Osaka
- Assignee: Nitto Denko Corporation
- Current Assignee: Nitto Denko Corporation
- Current Assignee Address: JP Ibaraki, Osaka
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: JP2004-382791 20041222
- International Application: PCT/JP2005/023619 WO 20051222
- International Announcement: WO2006/068232 WO 20060629
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K9/14 ; A61K31/07 ; C12N15/11

Abstract:
An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
Public/Granted literature
- US20080193512A1 Drug Carrier and Drug Carrier Kit for Inhibiting Fibrosis Public/Granted day:2008-08-14
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