A fuel cell system and method for controlling relative humidity in a fuel cell system. A controller can be signally coupled to one or more sensors and configured to operate at least one flow manipulation device in response to changes in a relative humidity of a reactant passing through the cathode flowpath of the fuel cell in order to maintain the relative humidity within a prescribed range. The controller correlates one or more of a temperature setpoint, pressure setpoint, stoichiometry setpoint or actual operating condition of any of them to an operating condition of the system. In this way, a desired level of relative humidity can be achieved, maintained or both while minimizing the use of power-robbing flow manipulation devices, such as a pump, compressor, fan or related component.