Invention Grant
US08173363B2 Random transposon insertion in Staphylococcus aureus and use thereof to identify essential genes
失效
金黄色葡萄球菌中的随机转座子插入及其用于鉴定必需基因
- Patent Title: Random transposon insertion in Staphylococcus aureus and use thereof to identify essential genes
- Patent Title (中): 金黄色葡萄球菌中的随机转座子插入及其用于鉴定必需基因
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Application No.: US10525062Application Date: 2003-08-20
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Publication No.: US08173363B2Publication Date: 2012-05-08
- Inventor: Kim Folger Bruce , Paul Warrener , Jennifer McLarnan , Kevin Hou
- Applicant: Kim Folger Bruce , Paul Warrener , Jennifer McLarnan , Kevin Hou
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines and Diagnostics, Inc.
- Current Assignee: Novartis Vaccines and Diagnostics, Inc.
- Current Assignee Address: US CA Emeryville
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US03/25879 WO 20030820
- International Announcement: WO2004/018624 WO 20040304
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; G01N33/48
Abstract:
The invention provides a method for generating a database of candidate essential genes in Staphylococcus aureus, as well as otherwise important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing S. aureus infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing Staphylococcus infection.
Public/Granted literature
- US20060234233A1 Random transposon insertion in staphylococcus aureus and use thereof to identify essential genes Public/Granted day:2006-10-19
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