Invention Grant
US08173364B2 Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
有权
用于生产正交tRNA-氨酰基tRNA合成酶对的方法和组成
- Patent Title: Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
- Patent Title (中): 用于生产正交tRNA-氨酰基tRNA合成酶对的方法和组成
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Application No.: US11978221Application Date: 2007-10-26
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Publication No.: US08173364B2Publication Date: 2012-05-08
- Inventor: Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
- Applicant: Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
- Applicant Address: US CA La Jolla US CA Oakland
- Assignee: The Scripps Research Institute,The Regents of the University of California
- Current Assignee: The Scripps Research Institute,The Regents of the University of California
- Current Assignee Address: US CA La Jolla US CA Oakland
- Agency: Quine Intellectual Property Law Group, P.C.
- Agent Paul Littlepage
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N15/12 ; C12P21/00
Abstract:
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Public/Granted literature
- US20090053791A1 Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs Public/Granted day:2009-02-26
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