Invention Grant
US08173373B2 Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling
有权
筛选调节鲜味信号的化合物的T1R1 / T1R3异聚受体的方法
- Patent Title: Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling
- Patent Title (中): 筛选调节鲜味信号的化合物的T1R1 / T1R3异聚受体的方法
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Application No.: US12270846Application Date: 2008-11-13
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Publication No.: US08173373B2Publication Date: 2012-05-08
- Inventor: Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
- Applicant: Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
- Applicant Address: US CA San Diego
- Assignee: Senomyx, Inc.
- Current Assignee: Senomyx, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Hunton & Williams LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/567
Abstract:
Methods for screening compounds that modulate umami taste signaling in taste cells are provided. These methods comprise contacting a compound with hetero-oligomeric taste transduction G-protein coupled receptors that respond to umami taste stimuli, and determining whether the compound binds to and/or affects the activity of the hetero-oligomeric umami receptor.
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