Invention Grant
US08173378B2 Methods of using an alpha-1-adrenergic receptor having altered ligand affinity
失效
使用具有改变的配体亲和力的α-1-肾上腺素能受体的方法
- Patent Title: Methods of using an alpha-1-adrenergic receptor having altered ligand affinity
- Patent Title (中): 使用具有改变的配体亲和力的α-1-肾上腺素能受体的方法
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Application No.: US12451558Application Date: 2008-05-22
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Publication No.: US08173378B2Publication Date: 2012-05-08
- Inventor: Ikunobu Muramatsu
- Applicant: Ikunobu Muramatsu
- Applicant Address: JP Fukui JP Tokyo
- Assignee: Pharmacome LLC,Nippon Chemiphar Co., Ltd.
- Current Assignee: Pharmacome LLC,Nippon Chemiphar Co., Ltd.
- Current Assignee Address: JP Fukui JP Tokyo
- Agency: Edwards Wildman Palmer LLP
- Agent David G. Conlin; Kathryn A. Piffat, Esq.
- Priority: JP2007-137275 20070523
- International Application: PCT/JP2008/059459 WO 20080522
- International Announcement: WO2008/146707 WO 20081204
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12P21/06 ; C12N1/20 ; C12N15/74
Abstract:
A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has been expressed. This makes it possible to provide a technique for analyzing the function of many putative GPCRs whose entities have not been clarified.
Public/Granted literature
- US20100120068A1 G-protein-conjugated receptor having altered ligand affinity, and use thereof Public/Granted day:2010-05-13
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