Invention Grant
US08173402B2 Modified yeasts and uses thereof, in particular for producing steroid derivatives
有权
改良的酵母及其用途，特别是用于生产类固醇衍生物
- Patent Title: Modified yeasts and uses thereof, in particular for producing steroid derivatives
- Patent Title (中): 改良的酵母及其用途，特别是用于生产类固醇衍生物
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Application No.: US13006607Application Date: 2011-01-14
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Publication No.: US08173402B2Publication Date: 2012-05-08
- Inventor: Bruno Dumas , Gilles Cauet , Eric Degryse , Tilman Achstetter
- Applicant: Bruno Dumas , Gilles Cauet , Eric Degryse , Tilman Achstetter
- Applicant Address: FR Antony
- Assignee: Aventis Pharma S.A.
- Current Assignee: Aventis Pharma S.A.
- Current Assignee Address: FR Antony
- Agent J. Darrell Fontenot
- Priority: FR0010437 20000808
- Main IPC: C12P7/00
- IPC: C12P7/00 ; C12N15/00 ; C12N1/20 ; C12N1/14 ; C12N9/00 ; C12N9/04 ; C12Q1/34 ; C12Q1/26 ; C07H21/04 ; C07H21/02
Abstract:
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activity, in particular by modifying the GCY1 and/or YPR1 genes. The yeast strains of the invention make it possible to improve the efficiency of the synthesis or to increase the selectivity or the yields of the method, as well as the quality of the final product. The strains, methods and compounds of the invention are useful in the search for, the development and the production of products with therapeutic or prophylactic activity, in humans or animals, in particular of steroidal derivatives.
Public/Granted literature
- US20110104749A1 MODIFIED YEASTS AND USES THEREOF, IN PARTICULAR FOR PRODUCING STEROID DERIVATIVES Public/Granted day:2011-05-05
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