Invention Grant
US08173411B2 Drying process for preserving an active agent as a highly viscous liquid
失效
用于保存活性剂作为高粘度液体的干燥过程
- Patent Title: Drying process for preserving an active agent as a highly viscous liquid
- Patent Title (中): 用于保存活性剂作为高粘度液体的干燥过程
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Application No.: US11587023Application Date: 2005-04-28
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Publication No.: US08173411B2Publication Date: 2012-05-08
- Inventor: Yves Mayeresse
- Applicant: Yves Mayeresse
- Applicant Address: BE Rixensart
- Assignee: GlaxoSmithKline Biologicals S.A.
- Current Assignee: GlaxoSmithKline Biologicals S.A.
- Current Assignee Address: BE Rixensart
- Agent Michael M. Conger
- Priority: GB0409795.2 20040430
- International Application: PCT/EP2005/004638 WO 20050428
- International Announcement: WO2005/105978 WO 20051110
- Main IPC: C12N1/00
- IPC: C12N1/00 ; A61K39/13 ; A61K39/29
Abstract:
The present invention relates to a method of drying biological and other labile samples so that they can be preserved as a highly viscous liquid. The method involves the steps of preparing a preservation sample by dissolving/suspending an active agent in a solution of a stabilizing agent, subjecting the preservation sample to such temperature and pressure conditions that the preservation sample looses solvent by evaporation without freezing or bubbling to form a foam and removing solvent until the preservation sample dries to form a highly viscous liquid. The stabilizing solution comprises a glass forming polyol and a second component which decreases the flow rate of the highly viscous liquid formed by the method.
Public/Granted literature
- US20070298052A1 Drying Process for Presserving an Active Agent as a Higly Viscous Liquid Public/Granted day:2007-12-27
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