Invention Grant
- Patent Title: Circuit arrangement for injecting nucleic acids and other biologically active molecules into the nucleus of higher eucaryotic cells using electrical current
- Patent Title (中): 使用电流将核酸和其他生物活性分子注入高级真核细胞核的电路装置
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Application No.: US10475840Application Date: 2002-04-23
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Publication No.: US08173416B2Publication Date: 2012-05-08
- Inventor: Herbert Müller-Hartmann , Gudula Riemen , Kirsten Rothmann-Cosic , Corinna Thiel , Ludger Altrogge , Meike Weigel , Rainer Christine , Elke Lorbach , Juliana Helfrich , Heike Wessendorf , Gregor Siebenkotten
- Applicant: Herbert Müller-Hartmann , Gudula Riemen , Kirsten Rothmann-Cosic , Corinna Thiel , Ludger Altrogge , Meike Weigel , Rainer Christine , Elke Lorbach , Juliana Helfrich , Heike Wessendorf , Gregor Siebenkotten
- Applicant Address: DE Cologne
- Assignee: Lonza Cologne GmbH
- Current Assignee: Lonza Cologne GmbH
- Current Assignee Address: DE Cologne
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: DE10119901 20010423
- International Application: PCT/DE02/01489 WO 20020423
- International Announcement: WO02/086129 WO 20021031
- Main IPC: C12M1/42
- IPC: C12M1/42 ; C12M3/00 ; F41B15/04 ; H01T23/00
Abstract:
The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality.
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