Invention Grant
- Patent Title: Diagnosis and treatment of T-cell acute lymphoblastic leukemia
- Patent Title (中): T细胞急性淋巴细胞白血病的诊断与治疗
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Application No.: US12312355Application Date: 2007-11-07
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Publication No.: US08173423B2Publication Date: 2012-05-08
- Inventor: Peter Marynen , Jan Cools , Idoya Lahortiga
- Applicant: Peter Marynen , Jan Cools , Idoya Lahortiga
- Applicant Address: BE Ghent BE Leuven
- Assignee: VIB VZW,Katholieke Universiteit Leuven, K.U. Leuven R&D
- Current Assignee: VIB VZW,Katholieke Universiteit Leuven, K.U. Leuven R&D
- Current Assignee Address: BE Ghent BE Leuven
- Agency: TraskBritt
- International Application: PCT/EP2007/061988 WO 20071107
- International Announcement: WO2008/055924 WO 20080515
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12Q15/63 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to the field of biotechnological means to diagnose or treat T-cell acute lymphoblastic leukaemia. More particularly, the invention relates to methods to diagnose T-cell acute lymphoblastic leukaemia via determining the presence of a duplication of the MYB gene in cells taken from patients. The invention further relates to inhibitors capable of neutralizing the biological activity of MYB alone, or in combination with inhibitors capable of neutralizing the biological activity of NOTCH1, which can be used to treat T-cell acute lymphoblastic leukaemia.
Public/Granted literature
- US20100130586A1 DIAGNOSIS AND TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA Public/Granted day:2010-05-27
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