Invention Grant
- Patent Title: Variants of pigment epithelium derived factor and uses thereof
- Patent Title (中): 色素上皮衍生因子的变体及其用途
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Application No.: US11718873Application Date: 2004-11-16
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Publication No.: US08173591B2Publication Date: 2012-05-08
- Inventor: Rony Seger , Galia Maik-Rachline
- Applicant: Rony Seger , Galia Maik-Rachline
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co.
- Current Assignee: Yeda Research and Development Co.
- Current Assignee Address: IL Rehovot
- Agency: Booth Udall, PLC
- Agent Rodney J. Fuller
- International Application: PCT/IL2004/001052 WO 20041116
- International Announcement: WO2006/054278 WO 20060526
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/475 ; A61P35/00
Abstract:
The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.
Public/Granted literature
- US20090269320A1 VARIANTS OF PIGMENT EPITHELIUM DERIVED FACTOR AND USES THEREOF Public/Granted day:2009-10-29
Information query
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