Invention Grant
- Patent Title: Caspase-2 inhibitors and their biological applications
- Patent Title (中): 胱天蛋白酶-2抑制剂及其生物应用
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Application No.: US11579202Application Date: 2005-05-02
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Publication No.: US08173600B2Publication Date: 2012-05-08
- Inventor: David Chauvier , Richard Casimir , Etienne Jacotot , Dominique Rebouillat
- Applicant: David Chauvier , Richard Casimir , Etienne Jacotot , Dominique Rebouillat
- Applicant Address: IT Parma
- Assignee: Chiesi Farmaceutici S.p.A.
- Current Assignee: Chiesi Farmaceutici S.p.A.
- Current Assignee Address: IT Parma
- Agency: Nixon & Vanderhye P.C.
- International Application: PCT/EP2005/005493 WO 20050502
- International Announcement: WO2005/105829 WO 20051110
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/55 ; C07K7/06
Abstract:
The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone: 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Valinyl-L-Alanyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester SEQ ID NO:1) and derivatives thereof, SEQ ID NO:1 corresponding to formulae Ia or Ib. Application of the inhibitors for preventing and treating diseases involving caspase-2.
Public/Granted literature
- US20080311051A1 Caspase-2 Inhibitors And Their Biological Applications Public/Granted day:2008-12-18
Information query
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