Invention Grant
- Patent Title: Aminodihydrothiazine derivatives
- Patent Title (中): 氨基二氢噻嗪衍生物
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Application No.: US12089409Application Date: 2006-10-23
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Publication No.: US08173642B2Publication Date: 2012-05-08
- Inventor: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
- Applicant: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2005-309642 20051025; JP2006-076636 20060320
- International Application: PCT/JP2006/321015 WO 20061023
- International Announcement: WO2007/049532 WO 20070503
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D417/14 ; A61K31/497 ; A61K31/54
Abstract:
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
Public/Granted literature
- US20090082560A1 AMINODIHYDROTHIAZINE DERIVATIVES Public/Granted day:2009-03-26
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