Invention Grant
US08173662B2 Fused pyrimidines as inhibitors of nucleoside phosphorylases and nucleosidases
有权
融合嘧啶作为核苷磷酸酶和核苷酸酶的抑制剂
- Patent Title: Fused pyrimidines as inhibitors of nucleoside phosphorylases and nucleosidases
- Patent Title (中): 融合嘧啶作为核苷磷酸酶和核苷酸酶的抑制剂
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Application No.: US12455537Application Date: 2009-06-03
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Publication No.: US08173662B2Publication Date: 2012-05-08
- Inventor: Gary Brian Evans , Richard Hubert Furneaux , Dirk Henning Lenz , Vern L. Schramm , Peter Charles Tyler , Olga Vladimirovna Zubkova
- Applicant: Gary Brian Evans , Richard Hubert Furneaux , Dirk Henning Lenz , Vern L. Schramm , Peter Charles Tyler , Olga Vladimirovna Zubkova
- Applicant Address: NZ Auckland US NY Bronx
- Assignee: Industrial Research Limited,Albert Einstein College of Medicine of Yeshiva University
- Current Assignee: Industrial Research Limited,Albert Einstein College of Medicine of Yeshiva University
- Current Assignee Address: NZ Auckland US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- Priority: NZ520919 20020821
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P35/04 ; A61P31/04 ; A61P37/06 ; A61P33/02
Abstract:
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
Public/Granted literature
- US20090239885A1 Inhibitors of nucleoside phoshorylases and nucleosidases Public/Granted day:2009-09-24
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