Invention Grant
US08173677B2 Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor
有权
使用烟酰胺磷酸核糖转移酶抑制剂来影响NAD +水平的组合物和方法
- Patent Title: Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor
- Patent Title (中): 使用烟酰胺磷酸核糖转移酶抑制剂来影响NAD +水平的组合物和方法
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Application No.: US12410930Application Date: 2009-03-25
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Publication No.: US08173677B2Publication Date: 2012-05-08
- Inventor: Anne Roulston , Pierre Beauparlant
- Applicant: Anne Roulston , Pierre Beauparlant
- Applicant Address: CA Montreal
- Assignee: Gemin X Pharmaceuticals Canada Inc.
- Current Assignee: Gemin X Pharmaceuticals Canada Inc.
- Current Assignee Address: CA Montreal
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; A61K31/4425 ; A61P35/02
Abstract:
The present invention relates to methods for decreasing cellular DNA repair in a patient diagnosed with or suspected to have chronic lymphocytic leukemia (CLL); decreasing cellular NAD+ biosynthesis in a patient diagnosed with or suspected to have CLL; or sensitizing a patient diagnosed with or suspected to have CLL to a DNA damaging therapy. The invention relates to methods for treating a patient diagnosed with or suspected to have CLL.
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