Invention Grant
- Patent Title: Pyridone derivatives as p38α MAPK inhibitors
- Patent Title (中): 吡啶酮衍生物作为p38αMAPK抑制剂
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Application No.: US12597926Application Date: 2008-05-02
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Publication No.: US08173684B2Publication Date: 2012-05-08
- Inventor: Chiyoshi Kasahara , Hitoshi Yamazaki
- Applicant: Chiyoshi Kasahara , Hitoshi Yamazaki
- Applicant Address: JP Tokyo JP Osaka-shi
- Assignee: Astellas Pharma Inc.,Wakunaga Pharmaceutical Co., Ltd.
- Current Assignee: Astellas Pharma Inc.,Wakunaga Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo JP Osaka-shi
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- International Application: PCT/JP2008/058689 WO 20080502
- International Announcement: WO2008/140066 WO 20081120
- Main IPC: C07D213/82
- IPC: C07D213/82 ; A61K31/44

Abstract:
A compound represented by the formula (I): wherein R1 is lower alkyl, cycloalkyl or aromatic hydrocarbon ring, each of which is optionally substituted with one or more substituents; R2 is hydrogen atom, halogen atom, lower alkyl, halo(lower)alkyl or lower alkoxy; and R3 is (1) a group represented by the formula: wherein R4 is lower alkyl, etc.; (2) a group represented by the formula: wherein R5 is lower alkyl, etc.; (3) a group represented by the formula: wherein R6 is lower alkyl, etc.; or (4) a group selected from halogen atom, carboxy, hydroxy and lower alkoxy, or a salt thereof.
Public/Granted literature
- US20100063098A1 PYRIDONE DERIVATIVES AS P38A MAPK INHIBITORS Public/Granted day:2010-03-11
Information query
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