Invention Grant
- Patent Title: Inhibitors of cysteine proteases and methods of use thereof
- Patent Title (中): 半胱氨酸蛋白酶抑制剂及其使用方法
-
Application No.: US12138806Application Date: 2008-06-13
-
Publication No.: US08173696B2Publication Date: 2012-05-08
- Inventor: Rogelio Siles , Ming Zhou , J. Freeland Ackley , Kevin G. Pinney , Shen-En Chen , Wara Milenka Arispe-Angulo , Mary Lynn Trawick
- Applicant: Rogelio Siles , Ming Zhou , J. Freeland Ackley , Kevin G. Pinney , Shen-En Chen , Wara Milenka Arispe-Angulo , Mary Lynn Trawick
- Applicant Address: US TX Waco
- Assignee: Baylor University
- Current Assignee: Baylor University
- Current Assignee Address: US TX Waco
- Agent Karen E. Flick
- Main IPC: A61K31/382
- IPC: A61K31/382
Abstract:
The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
Public/Granted literature
- US20090076076A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF Public/Granted day:2009-03-19
Information query
