Invention Grant
US08173767B2 Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
有权
用于HIV的合成肽疫苗：CBD表位作为有效的免疫原，以引发广泛中和抗HIV的抗体
- Patent Title: Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
- Patent Title (中): 用于HIV的合成肽疫苗：CBD表位作为有效的免疫原，以引发广泛中和抗HIV的抗体
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Application No.: US12073887Application Date: 2008-03-11
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Publication No.: US08173767B2Publication Date: 2012-05-08
- Inventor: Ara Hovanessian , Jean-Paul Briand , Sylviane Muller , Bernard Krust , Josette Svab , Elias Said
- Applicant: Ara Hovanessian , Jean-Paul Briand , Sylviane Muller , Bernard Krust , Josette Svab , Elias Said
- Applicant Address: FR Paris FR Paris
- Assignee: Institut Pasteur,Centre National de la Recherche Scientifique
- Current Assignee: Institut Pasteur,Centre National de la Recherche Scientifique
- Current Assignee Address: FR Paris FR Paris
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP03290919 20030411
- Main IPC: C07K5/00
- IPC: C07K5/00
Abstract:
The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response against HIV infection. Compositions, pharmaceutical compositions and vaccines comprising these antigenic peptides are also encompassed by the present invention, as well as neutralizing antibodies which inhibit infection of primary CD4+ T lymphocytes by various HIV isolates. Methods for diagnosis of HIV are also disclosed.
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