Invention Grant
- Patent Title: Polypeptides and use thereof
- Patent Title (中): 多肽及其用途
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Application No.: US12297860Application Date: 2007-04-20
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Publication No.: US08173774B2Publication Date: 2012-05-08
- Inventor: Christina Furebring , Johannes A. G. Van Strijp , Petrus J. A. Haas , Anna Rosen , Karin Haraldsson , Erika Gustafsson , Lena Schultz , Cornelis P. M. Van Kessel
- Applicant: Christina Furebring , Johannes A. G. Van Strijp , Petrus J. A. Haas , Anna Rosen , Karin Haraldsson , Erika Gustafsson , Lena Schultz , Cornelis P. M. Van Kessel
- Applicant Address: SE Lund
- Assignee: Alligator Bioscience AB
- Current Assignee: Alligator Bioscience AB
- Current Assignee Address: SE Lund
- Agency: Morrison & Foerster LLP
- Priority: GB0607798.6 20060420
- International Application: PCT/GB2007/001443 WO 20070420
- International Announcement: WO2007/122400 WO 20071101
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K16/00 ; C07K17/00 ; C07K14/00 ; C07K5/00 ; C07K7/00 ; A61K38/00 ; A61K39/00 ; A61K39/38 ; A61K39/085 ; A61K39/09 ; A61K39/02
Abstract:
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.
Public/Granted literature
- US20100298539A1 NOVEL POLYPEPTIDES AND USE THEREOF Public/Granted day:2010-11-25
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