Invention Grant
US08173792B2 Method for regulating protein function in cells using synthetic small molecules
有权
使用合成小分子调节细胞蛋白质功能的方法
- Patent Title: Method for regulating protein function in cells using synthetic small molecules
- Patent Title (中): 使用合成小分子调节细胞蛋白质功能的方法
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Application No.: US12069235Application Date: 2008-02-08
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Publication No.: US08173792B2Publication Date: 2012-05-08
- Inventor: Thomas J. Wandless , Laura Anne Banaszynski , Mari Iwamoto , Lystranne Alysia Maynard , Ling-chun Chen
- Applicant: Thomas J. Wandless , Laura Anne Banaszynski , Mari Iwamoto , Lystranne Alysia Maynard , Ling-chun Chen
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: King & Spalding LLP
- Agent Judy M. Mohr; Stephen Todd
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/63 ; A01K67/00
Abstract:
Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.
Public/Granted literature
- US20090215169A1 Method for regulating protein function in cells using synthetic small molecules Public/Granted day:2009-08-27
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