Invention Grant
- Patent Title: sEH inhibitors and their use
- Patent Title (中): sEH抑制剂及其用途
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Application No.: US12682073Application Date: 2008-10-10
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Publication No.: US08173805B2Publication Date: 2012-05-08
- Inventor: Yun Ding , Reema K. Thalji , Joseph P. Marino, Jr.
- Applicant: Yun Ding , Reema K. Thalji , Joseph P. Marino, Jr.
- Applicant Address: US PA Philadelphia
- Assignee: GlaxoSmithKline, LLC
- Current Assignee: GlaxoSmithKline, LLC
- Current Assignee Address: US PA Philadelphia
- Agent Linda E. Hall; John L. Lemanowicz
- International Application: PCT/US2008/079517 WO 20081010
- International Announcement: WO2009/049157 WO 20090416
- Main IPC: C07D251/54
- IPC: C07D251/54 ; C07D403/12 ; C07D403/14 ; A61K31/53 ; A61P9/08 ; A61P9/10 ; A61P9/12 ; A61P11/06 ; A61P11/00 ; A61P13/12
Abstract:
The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Public/Granted literature
- US20100210656A1 NOVEL sEH INHIBITORS AND THEIR USE Public/Granted day:2010-08-19
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