Invention Grant
US08173814B2 Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
有权
（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式
![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/docs/US/2012-05-08/US08173814B2/abs.jpg.600x600.jpg)
- Patent Title: Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
- Patent Title (中): （E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式
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Application No.: US13181375Application Date: 2011-07-12
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Publication No.: US08173814B2Publication Date: 2012-05-08
- Inventor: Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
- Applicant: Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
- Applicant Address: US NJ Madison
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NJ Madison
- Agency: Jones Day
- Main IPC: C07D215/44
- IPC: C07D215/44
![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/abs-image/US/2012/05/08/US08173814B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
Public/Granted literature
- US20110313166A1 MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF Public/Granted day:2011-12-22
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