Invention Grant
US08173820B2 Compounds which potentiate the AMPA receptor and uses thereof in medicine
失效
增强AMPA受体的化合物及其在药物中的用途
- Patent Title: Compounds which potentiate the AMPA receptor and uses thereof in medicine
- Patent Title (中): 增强AMPA受体的化合物及其在药物中的用途
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Application No.: US12808197Application Date: 2008-12-17
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Publication No.: US08173820B2Publication Date: 2012-05-08
- Inventor: Nicolas Bertheleme , Wai Ngor Chan , Jaqueline Sandra Scott , Simon E. Ward
- Applicant: Nicolas Bertheleme , Wai Ngor Chan , Jaqueline Sandra Scott , Simon E. Ward
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent Bonnie L. Deppenbrock
- Priority: GB0724783.6 20071219; GB0818068.9 20081002
- International Application: PCT/EP2008/067681 WO 20081217
- International Announcement: WO2009/080637 WO 20090702
- Main IPC: C07D211/72
- IPC: C07D211/72 ; C07D213/62 ; C07C303/00 ; A61K31/44 ; A61K31/16

Abstract:
Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
Public/Granted literature
- US20110021578A1 Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine Public/Granted day:2011-01-27
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