Invention Grant
US08173860B2 Non-human transgenic mammal expressing a human FcRn on its mammary gland cells and expressing a transgenic protein-human Fc-domain fusion
有权
在其乳腺细胞上表达人FcRn并表达转基因蛋白质 - 人Fc结构域融合的非人转基因哺乳动物
- Patent Title: Non-human transgenic mammal expressing a human FcRn on its mammary gland cells and expressing a transgenic protein-human Fc-domain fusion
- Patent Title (中): 在其乳腺细胞上表达人FcRn并表达转基因蛋白质 - 人Fc结构域融合的非人转基因哺乳动物
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Application No.: US11788775Application Date: 2007-04-20
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Publication No.: US08173860B2Publication Date: 2012-05-08
- Inventor: Harry M. Meade , Daniel Pollock
- Applicant: Harry M. Meade , Daniel Pollock
- Applicant Address: US MA Framingham
- Assignee: GTC Biotherapeutics, Inc.
- Current Assignee: GTC Biotherapeutics, Inc.
- Current Assignee Address: US MA Framingham
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A01K67/00
- IPC: A01K67/00 ; C12P21/00
Abstract:
The invention provides, in part, methods for the production of proteins in a transgenic non-human mammal, wherein the proteins are transported from the blood to the mammary gland for secretion in milk. The transport of the protein to the mammary gland and/or milk is facilitated by binding to a transport receptor in the mammary gland.
Public/Granted literature
- US20080063780A1 Methods and products related to the transfer of molecules from blood to the mammary gland Public/Granted day:2008-03-13
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