A temperature controlled mouse includes a central controller, a driver control circuit, a temperature control circuit, and a signal transmitting circuit. The driver control circuit generates coordinate control signals and pointer clicking signals, and the signals are transmitted to a host computer coupled to the mouse via the signal transmitting circuit. The temperature control circuit detects the changes of the temperature from a user's hand and thereby generates temperature control signals. The central controller controls the operation status of the mouse according to the temperature control signals, wherein when the temperature detected is within a predetermined temperature range, the central controller wakes the mouse and allows the transmission of signals from the mouse to the host computer; otherwise the central controller stops the transmission of signals. The temperature controlled mouse prevents accidental activation due to negligent bump. Thereby the mouse may only wake from purposeful control and thereby conserves energy.