Invention Grant
US08174702B2 Speckle reduction in optical coherence tomography by path length encoded angular compounding
有权
光学相干断层扫描中的斑点减少通过路径长度编码角复合
- Patent Title: Speckle reduction in optical coherence tomography by path length encoded angular compounding
- Patent Title (中): 光学相干断层扫描中的斑点减少通过路径长度编码角复合
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Application No.: US12510047Application Date: 2009-07-27
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Publication No.: US08174702B2Publication Date: 2012-05-08
- Inventor: Guillermo J. Tearney , Nicusor Iftimia , Brett E. Bouma
- Applicant: Guillermo J. Tearney , Nicusor Iftimia , Brett E. Bouma
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Dorsey & Whitney LLP
- Main IPC: G01B9/02
- IPC: G01B9/02 ; G01B11/02

Abstract:
Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
Public/Granted literature
- US20100157309A1 SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING Public/Granted day:2010-06-24
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