A time division duplex wireless communication system based on Code Spreading-Orthogonal Frequency Division Multiple Access (CS-OFDMA) and a smart antenna includes: an antenna array and multichannel transceiver, a space processor, a demodulator, an L2 processor and a modulator. The CS-OFDMA system provided by the present invention combines synchronous CDMA technique and OFDMA technique, overcomes the severe ISI caused by spectrum-spreading by the conventional CDMA system while transmitting wideband data, effectively counteracts frequency-selective fading and inter-cell interference, and is beneficial to reliable transmission of narrowband voice and wideband data and also beneficial to co-frequency networking.