A method and apparatus for controlling the transmit power of a mobile device in a mobile communication network takes the level of self-interference into account to perform inner-loop power control. For normal inner-loop power control, a signal quality estimate is compared to a signal quality target and power control commands are generated based on the comparison. When self-interference is the dominant impairment in the received signal, a “fast break” is introduced to change inner-loop power control command generation. The amount of self-interference is determined based on the delay spread of the channel.