A system and method of processing images of a region of interest of a patient is provided. The method comprises acquiring a reference image of the region of interest of the patient; during a pullback of an intravascular sensor in the region of interest, triggering simultaneously the steps of: acquiring a data collected by the sensor characteristic of the region of interest; and acquiring a succession of images of the region of interest associated with the location of the intravascular sensor when acquiring the data, respectively. The method further includes registering the succession of images; associating the location of the intravascular sensor relative to the step of acquiring the data collected by the intravascular sensor; and displaying and positioning the data collected by the intravascular sensor on the reference image in correspondence to the location of the intravascular sensor at the respective step of acquiring the data.