A method for generating a design-specific timing specification includes inputting a first timing specification of a target device corresponding to a first timing yield. The first timing specification contains timing delays of elements located in at least first and second regions of the target device. A circuit design is placed and routed. With a programmed processor, the timing delay of the first timing specification is increased for one or more elements implementing the circuit design in the first region to produce a second timing specification, and a second timing yield of target device is determined from the second timing specification. In response to the second timing yield being larger than a target timing yield, the programmed processor decreases the timing delay of the second timing specification for one or more elements in the second region to compensate for a difference between the second timing yield and the target timing yield to produce a design-specific timing specification.