A liquid dispensing vending system that includes a closed, integrated system of bottles and dispensing machines. The bottles used with the instant dispensing system are designed to minimize the growth of mold, mildew, bacteria and other harmful micro organisms. The vending system may be used to dispense water, soft drinks, coffee, tea, water with nutrients, and/or antioxidants, into containers such as rugged bottles capable of being reused many times. The bottles are designed to be refilled by the dispensing machines, and therefore are tampered resistant. The bottles are made of an antimicrobial plastic and their contents are stored under pressure to discourage bacterial and organic growth inside the bottle.